Primary Information |
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| BoMiProt ID | Bomi2427 |
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| Protein Name | NADH-cytochrome b5 reductase 3 |
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| Organism | Bos taurus |
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| Uniprot ID | P07514 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_001096720.1 |
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| Aminoacid Length | 301 |
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| Molecular Weight | 34122 |
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| FASTA Sequence |
Download |
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| Gene Name | CYB5R3 |
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| Gene ID | 515773 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Cytochrome b5 reductase 3 as the first identified physiological sGC heme iron reductase in vascular smooth muscle cells, serving as a critical regulator of cGMP production and protein kinase G-dependent signaling. |
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| Biochemical Properties | NADH cytochrome b5 reductase 3 (Cyb5R3) or methemoglobin reductase is a flavoprotein known for its ability to transfer electrons from its NADH domain through the small heme protein partner cytochrome b5 (Cyb5) to a final electron acceptor. |
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| PTMs | N6-acetylation at Lysine,Phosphorylation at Tyrosine,N-myristoylation at Glycine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5. PMID: 28584062; PMCID: PMC5527687. |
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