Primary Information |
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| BoMiProt ID | Bomi2416 |
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| Protein Name | Cation-independent mannose-6-phosphate receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P08169 |
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| Milk Fraction | Whey, MFGM, Exosome |
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| Ref Sequence ID | NP_776777.1 |
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| Aminoacid Length | 2499 |
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| Molecular Weight | 274529 |
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| FASTA Sequence |
Download |
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| Gene Name | IGF2R |
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| Gene ID | 281849 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Biochemical Properties | Functionally, the receptor binds IGF-II and M6P-containing ligands at distinct sites: repeat 11 comprises the core IGF-II binding site, whereas repeats 3, 5, 9, and 15 bind substrates with M6P groups. |
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| PTMs | N6-acetylation at Lysine,Phosphorylation at Serine,S-palmitoylation,Omega-N-methylation at Arginine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (2314-2336) |
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| Significance of PTMs | Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. |
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| PDB ID | 1Q25, 1SYO, 1SZ0, 2KVA, 2KVB, 6UM1, 6UM2, |
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| Additional Comments | The cation-independent mannose 6-phosphate receptor (CI-MPR) is responsible for the trafficking of mannose 6-phosphate-tagged proteins to lysosomes via Golgi sorting and from extracellular locations through endocytosis. |
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| Bibliography | 1.Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM, Corbett JA. Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. Mol Cell Biol. 2018 Mar 29;38(8):e00680-17. doi: 10.1128/MCB.00680-17. PMID: 29378831; PMCID: PMC5879465. 2.Brown J, Esnouf RM, Jones MA et al (2002) Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J 21(5):1054–1062. 3.Wang, Y.; MacDonald, R.G.; Thinakaran, G.; Kar, S. (2017). Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Molecular Neurobiology, 54(4), 2636–2658. doi:10.1007/s12035-016-9849-7 |
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