Primary Information |
---|
BoMiProt ID | Bomi241 |
---|
Protein Name | Dipeptidyl peptidase 1 |
---|
Organism | Bos taurus |
---|
Uniprot Id | Q3ZCJ8 |
---|
Milk Fraction | Whey |
---|
Ref Sequence Id | NP_001028789.1 |
---|
Aminoacid Length | 463 |
---|
Molecular Weight | 51949 |
---|
Fasta Sequence | https://www.uniprot.org/uniprot/Q3ZCJ8.fasta |
---|
Gene Name | CTSC |
---|
Gene Id | 352958 |
---|
Protein Existence Status | Reviewed: Experimental evidence at transcript level |
---|
Secondary Information |
---|
Protein Function | cystein cathepsin; involved in a normal cellular
protein degradation and turnover; aminodipeptidase |
---|
Biochemical Properties | Cysteine cathepsins are optimally active in a slightly acidic pH and
are mostly unstable at neutral pH; exhibit broad specificity, cleave
substrates preferentially after basic or hydrophobic residues; E-64 is a non-selective inhibitor
of all the cysteine cathepsins, with the exception of cathepsin C,
which is only weakly inhibited |
---|
Significance in milk | DPP4 is a key enzyme in intermediary metabolism by regulating important glycemic pathways; expression of DPP4 decreases with the onset of lactation |
---|
PTMs | Glycosylated: four glycans |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
---|
Predicted Disorder Regions | NA |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Bibliography | 1. Schulz, K. et al. (2015) ‘Effects of Inhibiting Dipeptidyl Peptidase-4 (DPP4) in Cows with Subclinical Ketosis.’, PloS one. Edited by M. Bader, 10(8), p. e0136078. doi: 10.1371/journal.pone.0136078. 2. Turk, B., Turk, D. and Turk, V. (2000) ‘Lysosomal cysteine proteases: more than scavengers.’, Biochimica et biophysica acta, 1477(1–2), pp. 98–111. doi: 10.1016/s0167-4838(99)00263-0. 3. Turk, D. et al. (2001) ‘Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases’, The EMBO Journal, 20(23), pp. 6570–6582. doi: 10.1093/emboj/20.23.6570. |