Primary Information |
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| BoMiProt ID | Bomi2408 |
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| Protein Name | Mitogen-activated protein kinase 13 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T0N5 |
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| Milk Fraction | Exosome |
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| Aminoacid Length | 366 |
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| Molecular Weight | 42229 |
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| FASTA Sequence |
Download |
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| Gene Name | MAPK13 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | p38 MAPK has the ability of activating the p38 MAPK signaling pathway. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. |
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| Additional Comments | The knockdown of MAPK13 also blocked the effect of miR‑23a‑5p in osteogenic differentiation of human bone marrow-derived mesenchymal stem cells(hBMSCs). |
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| Bibliography | 1.Ren G, Sun J, Li MM, Zhang YD, Li RH, Li YM. MicroRNA-23a-5p regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting mitogen-activated protein kinase-13. Mol Med Rep. 2018 Mar;17(3):4554-4560. doi: 10.3892/mmr.2018.8452. Epub 2018 Jan 18. PMID: 29344643. |
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