Primary Information
BoMiProt ID	Bomi2382
Protein Name	Lon protease homolog 2, peroxisomal
Organism	Bos taurus
Uniprot ID	Q3SX23
Milk Fraction	Whey
Ref Sequence ID	NP_001029895.1
Aminoacid Length	852
Molecular Weight	94310
FASTA Sequence	Download
Gene Name	LONP2
Gene ID	541085
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	Lon-2 is critical for B. burgdorferi to establish infection and to cope with environmental stresses.
Biochemical Properties	The canonical E. coli Lon is a hexameric serine protease composed of six identical 87-kDa subunits, each of which contains three functional domains including an N-terminal domain involved in substrate binding and recognition, a central ATPase domain associated with ATP binding and hydrolysis, and a C-terminal peptidase domain.
PTMs	N-acetylation at Serine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Mason C, Thompson C, Ouyang Z. The Lon-2 protease of Borrelia burgdorferi is critical for infection in the mammalian host. Mol Microbiol. 2020 May;113(5):938-950. doi: 10.1111/mmi.14460. Epub 2020 Jan 23. PMID: 31955462; PMCID: PMC8363874. 2.Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.Botos I, Melnikov EE, Cherry S, Khalatova AG, Rasulova FS, Tropea JE, Maurizi MR, Rotanova TV, Gustchina A, Wlodawer A J Struct Biol. 2004 Apr-May; 146(1-2):113-22. 3.Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease.Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, Wu SH, Chang YC, Lim C, Chang CI Structure. 2016 May 3; 24(5):676-686.