Primary Information |
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BoMiProt ID | Bomi2374 |
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Protein Name | LIM and SH3 domain protein 1 |
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Organism | Bos taurus |
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Uniprot ID | Q3B7M5 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001030471.1 |
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Aminoacid Length | 260 |
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Molecular Weight | 29677 |
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FASTA Sequence |
Download |
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Gene Name | LASP1 |
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Gene ID | 532851 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | LASP1 plays key roles in cell structure, physiological processes, and cell signaling. |
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Biochemical Properties | This protein contains an N-terminal LIM domain, which is composed of two sequential zinc-binding modules with a typical LIM motif, followed by tandem 35-residue nebulin-like repeats named R1 and R2, and by a C-terminal SRC homology region 3 (SH3) domain. Therefore MLN50 was renamed LIM and SH3 domain protein 1 (LASP1). As LASP1 is the first protein that combines both, LIM and SH3 domains, and as it contains two nebulin-like repeats, it defines a new LIM protein subfamily of the nebulin group. |
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PTMs | Phosphorylation at Ser/Thr,N6-acetylation at Lysine,N6-methylation at Lysine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | (123-204) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | LASP1 overexpression contributes to cancer aggressiveness hinting to a potential value of LASP1 as a cancer biomarker. |
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Bibliography | 1.Orth MF, Cazes A, Butt E, Grunewald TG. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. Oncotarget. 2015 Jan 1;6(1):26-42. doi: 10.18632/oncotarget.3083. PMID: 25622104; PMCID: PMC4381576. 2.Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.Tomasetto C, Moog-Lutz C, Régnier CH, Schreiber V, Basset P, Rio MC FEBS Lett. 1995 Oct 16; 373(3):245-9. 3.Linker region of nebulin family members plays an important role in targeting these molecules to cellular structures.Panaviene Z, Moncman CL Cell Tissue Res. 2007 Feb; 327(2):353-69. |