Search by BoMiProt ID - Bomi2374


Primary Information

BoMiProt ID Bomi2374
Protein Name LIM and SH3 domain protein 1
Organism Bos taurus
Uniprot IDQ3B7M5
Milk FractionExosome
Ref Sequence ID NP_001030471.1
Aminoacid Length 260
Molecular Weight 29677
FASTA Sequence Download
Gene Name LASP1
Gene ID 532851
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function  LASP1 plays key roles in cell structure, physiological processes, and cell signaling. 
Biochemical Properties This protein contains an N-terminal LIM domain, which is composed of two sequential zinc-binding modules with a typical LIM motif, followed by tandem 35-residue nebulin-like repeats named R1 and R2, and by a C-terminal SRC homology region 3 (SH3) domain. Therefore MLN50 was renamed LIM and SH3 domain protein 1 (LASP1). As LASP1 is the first protein that combines both, LIM and SH3 domains, and as it contains two nebulin-like repeats, it defines a new LIM protein subfamily of the nebulin group.
PTMs Phosphorylation at Ser/Thr,N6-acetylation at Lysine,N6-methylation at Lysine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions (123-204)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments LASP1 overexpression contributes to cancer aggressiveness hinting to a potential value of LASP1 as a cancer biomarker. 
Bibliography 1.Orth MF, Cazes A, Butt E, Grunewald TG. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. Oncotarget. 2015 Jan 1;6(1):26-42. doi: 10.18632/oncotarget.3083. PMID: 25622104; PMCID: PMC4381576. 2.Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.Tomasetto C, Moog-Lutz C, Régnier CH, Schreiber V, Basset P, Rio MC FEBS Lett. 1995 Oct 16; 373(3):245-9. 3.Linker region of nebulin family members plays an important role in targeting these molecules to cellular structures.Panaviene Z, Moncman CL Cell Tissue Res. 2007 Feb; 327(2):353-69.