Search by BoMiProt ID - Bomi2370


Primary Information

BoMiProt ID Bomi2370
Protein Name Protein kinase C beta type
Organism Bos taurus
Uniprot IDP05126
Milk FractionMFGM
Ref Sequence ID NP_777012.1
Aminoacid Length 671
Molecular Weight 76790
FASTA Sequence Download
Gene Name PRKCB
Gene ID 282325
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function A novel member of the protein kinase C (PKC) family of proteins is rapidly phosphorylated and activated during engagement of the type I IFN receptor. 
PTMs N-Acetylation at Ala, Phosphorylation at Ser/Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Inhibition of PKCβ restores the ischemia-induced NF-κB activity.
Bibliography 1.Alleboina S, Wong T, Singh MV, Dokun AO. Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes. Exp Biol Med (Maywood). 2020 May;245(9):785-796. doi: 10.1177/1535370220920832. Epub 2020 Apr 23. PMID: 32326759; PMCID: PMC7273893. 2.Redig AJ, Sassano A, Majchrzak-Kita B, Katsoulidis E, Liu H, Altman JK, Fish EN, Wickrema A, Platanias LC. Activation of protein kinase C{eta} by type I interferons. J Biol Chem. 2009 Apr 17;284(16):10301-14. doi: 10.1074/jbc.M807254200. Epub 2009 Feb 11. PMID: 19211565; PMCID: PMC2667717.