Primary Information |
|---|
| BoMiProt ID | Bomi2366 |
|---|
| Protein Name | Kinesin-like protein KIF2B |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | A6H750 |
|---|
| Milk Fraction | Exosome |
|---|
| Ref Sequence ID | NP_001094651.1 |
|---|
| Aminoacid Length | 683 |
|---|
| Molecular Weight | 76907 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | KIF2B |
|---|
| Gene ID | 538921 |
|---|
| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
|---|
Secondary Information |
|---|
| Protein Function | KIF2beta acts as a motor,responsible for the peripheral translocation of lysosomes. |
|---|
| Biochemical Properties | KIF2β has 171 nucleotides (57 amino acids, aa) less than KIF2, otherwise the two isoforms are identical (except for an alanine instead of a glycine at position 106).The missing amino acids are in non-conserved, variable domains of the protein and distributed in two regions: one (19 aa) is upstream and the other (38 aa) is downstream of the conserved protein motor domain.The motor domain of KIF2β is centrally localized and contains the conserved motifs typical of kinesin superfamily proteins. |
|---|
| PTMs | Phosphorylation at Serine |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors and the phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase. |
|---|
| Bibliography | 1.Santama N, Krijnse-Locker J, Griffiths G, Noda Y, Hirokawa N, Dotti CG. KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation. EMBO J. 1998 Oct 15;17(20):5855-67. doi: 10.1093/emboj/17.20.5855. PMID: 9774330; PMCID: PMC1170913. 2.Trayer,I.P. and Smith,J.K. (1997) Motoring down the highways of the cell.Trends Cell Biol., 7, 259–263. |
|---|
