Primary Information |
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BoMiProt ID | Bomi236 |
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Protein Name | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 |
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Organism | Bos taurus |
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Uniprot ID | E1BFE9 |
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Milk Fraction | Exosome |
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Aminoacid Length | 529 |
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Molecular Weight | 59190 |
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FASTA Sequence |
Download |
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Gene Name | BAIAP2L2 |
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Protein Existence Status | Reviewed: Protein inferred from homology |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | expressed in intestinal epithelial cells, kidney epithelial cells |
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Protein Function | sculpt cellular membranes, playing key roles in
processes such as endocytosis, cell motility and morphogenesis; promotes the formation of planar membrane sheets; interacts with phosphoinositide-rich membranes and binds to PIP2-headgroups in a
multivalent manner; involved in sculpting the membrane of these structures; may be involved in the formation of specific membrane structures at the
intercellular junctions of enterocytes |
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Biochemical Properties | contain an N-terminal I-BAR domain; N-terminal α-helix of the BAR domain of Pinkbar inserts into the bilayer- work together with the slightly negatively curved geometry of the membranebinding
interface of the BAR domain to stabilize flat membrane structures |
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PTMs | N-acetylation at Alanine,N6-methylation at Lysine,Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 222-229,239-248,261-309,421-450,480-485,511-525 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | 1. Pykäläinen, A. et al. (2011) ‘Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.’, Nature structural & molecular biology, 18(8), pp. 902–7. doi: 10.1038/nsmb.2079. 2. Oda, K. et al. (1999) ‘Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1’, Cytogenetic and Genome Research, 84(1–2), pp. 75–82. doi: 10.1159/000015219. |