Search by BoMiProt ID - Bomi236


Primary Information

BoMiProt ID Bomi236
Protein Name Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Organism Bos taurus
Uniprot IDE1BFE9
Milk FractionExosome
Aminoacid Length 529
Molecular Weight 59190
FASTA Sequence Download
Gene Name BAIAP2L2
Protein Existence Status Reviewed: Protein inferred from homology

Secondary Information

Presence in other biological fluids/tissue/cells expressed in intestinal epithelial cells, kidney epithelial cells
Protein Function sculpt cellular membranes, playing key roles in processes such as endocytosis, cell motility and morphogenesis; promotes the formation of planar membrane sheets; interacts with phosphoinositide-rich membranes and binds to PIP2-headgroups in a multivalent manner; involved in sculpting the membrane of these structures; may be involved in the formation of specific membrane structures at the intercellular junctions of enterocytes
Biochemical Properties contain an N-terminal I-BAR domain; N-terminal α-helix of the BAR domain of Pinkbar inserts into the bilayer- work together with the slightly negatively curved geometry of the membranebinding interface of the BAR domain to stabilize flat membrane structures
PTMs N-acetylation at Alanine,N6-methylation at Lysine,Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 222-229,239-248,261-309,421-450,480-485,511-525
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Pykäläinen, A. et al. (2011) ‘Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.’, Nature structural & molecular biology, 18(8), pp. 902–7. doi: 10.1038/nsmb.2079.
2. Oda, K. et al. (1999) ‘Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1’, Cytogenetic and Genome Research, 84(1–2), pp. 75–82. doi: 10.1159/000015219.