Primary Information |
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BoMiProt ID | Bomi2358 |
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Protein Name | Inositol 1,4,5-trisphosphate receptor type 1 |
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Organism | Bos taurus |
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Uniprot ID | Q9TU34 |
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Milk Fraction | Whey, Exosome |
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Ref Sequence ID | NP_777266.1 |
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Aminoacid Length | 2709 |
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Molecular Weight | 308318 |
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FASTA Sequence |
Download |
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Gene Name | ITPR1 |
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Gene ID | 317697 |
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Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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Protein Function | Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues.IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. |
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PTMs | Isopeptide bond formation, Lipolyation,S-Palmitoylation at Cyst,Phosphorylation at Serine, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1005-1029,1137-1168,1711-1751,1841-1866,2682-2709 |
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DisProt Annotation | |
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TM Helix Prediction | 6TMHs; (2234-2256), (2268-2285), (2300-2322), (2350-2372), (2400-2422), (2530-2552) |
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Significance of PTMs | Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48' and 'Lys-63'-linked. |
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Bibliography | Garcia MI, Boehning D. Cardiac inositol 1,4,5-trisphosphate receptors. Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):907-914. doi: 10.1016/j.bbamcr.2016.11.017. Epub 2016 Nov 22. PMID: 27884701; PMCID: PMC5511688. |