Search by BoMiProt ID - Bomi2358


Primary Information

BoMiProt ID Bomi2358
Protein Name Inositol 1,4,5-trisphosphate receptor type 1
Organism Bos taurus
Uniprot IDQ9TU34
Milk FractionWhey, Exosome
Ref Sequence ID NP_777266.1
Aminoacid Length 2709
Molecular Weight 308318
FASTA Sequence Download
Gene Name ITPR1
Gene ID 317697
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues.IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II.
PTMs Isopeptide bond formation, Lipolyation,S-Palmitoylation at Cyst,Phosphorylation at Serine, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1005-1029,1137-1168,1711-1751,1841-1866,2682-2709
DisProt Annotation
TM Helix Prediction 6TMHs; (2234-2256), (2268-2285), (2300-2322), (2350-2372), (2400-2422), (2530-2552)
Significance of PTMs Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48' and 'Lys-63'-linked.
Bibliography Garcia MI, Boehning D. Cardiac inositol 1,4,5-trisphosphate receptors. Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):907-914. doi: 10.1016/j.bbamcr.2016.11.017. Epub 2016 Nov 22. PMID: 27884701; PMCID: PMC5511688.