Primary Information
BoMiProt ID	Bomi2348
Protein Name	Importin-13
Organism	Bos taurus
Uniprot ID	A7YWD2
Milk Fraction	Whey
Ref Sequence ID	NP_001098860.1
Aminoacid Length	963
Molecular Weight	108139
FASTA Sequence	Download
Gene Name	IPO13
Gene ID	523399
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	The importin superfamily member Importin-13 is a bidirectional nuclear transporter.Importin-13 was revealed to bind to SP1 and KLF4 in a cellular context, with a key role in oxidative stress-dependent nuclear export of both transcription factors.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Inhibition of IPO13 transport activity itself might be an alternative and potential therapeutic strategy for NSCLC.
Bibliography	1.Gajewska KA, Lescesen H, Ramialison M, Wagstaff KM, Jans DA. Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response. Nat Commun. 2021 Oct 8;12(1):5904. doi: 10.1038/s41467-021-26125-x. PMID: 34625540; PMCID: PMC8501021. 2.Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, Yu W, Guo W, Qin Y, Cai X. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Cell Death Dis. 2020 Oct 20;11(10):879. doi: 10.1038/s41419-020-03101-9. PMID: 33082305; PMCID: PMC7575581.