Primary Information |
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BoMiProt ID | Bomi2342 |
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Protein Name | Inhibitor of nuclear factor kappa-B kinase-interacting protein |
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Organism | Bos taurus |
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Uniprot ID | A2VE53 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001075205.1 |
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Aminoacid Length | 349 |
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Molecular Weight | 39216 |
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FASTA Sequence |
Download |
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Gene Name | IKBIP |
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Gene ID | 540640 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | The IκB kinase (IKK) complex plays a vital role in regulating the NF-κB activation.IKIP peptide may be a promising therapeutic reagent in the prevention and treatment of inflammatory diseases. |
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Biochemical Properties | IκB kinase (IKK) complex is considered as a master regulator of NF-κB signaling, which contains two homologous catalytic subunits IKKα and IKKβ and a regulatory subunit NEMO (also known as IKKγ). IKKα and IKKβ have similar structure, comprising of an N-terminal kinase domain, a helix-loop-helix that functions in modulating IKK kinase activity, and a leucine zipper, whose role is to regulate homo- or heterodimerization of the kinases, followed by an NEMO‐binding domain (NBD). |
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PTMs | N-glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | (1-39) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | 1.Liu H, Yan Z, Zhao Y, Ma X, Zhang H, Wang X, Zhuang W, Zheng Y, Liu B, Zhang L, Gao C. A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. 2021 Sep 15;207(6):1652-1661. doi: 10.4049/jimmunol.2100397. Epub 2021 Aug 23. PMID: 34426543. 2.Hinz M. C.Scheidereit. 2014. The IκB kinase complex in NF-κB regulation and beyond. EMBO Rep. 15: 46–61. 3.Israël A. 2010. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb. Perspect. Biol. 2: a000158. |