Primary Information |
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BoMiProt ID | Bomi2315 |
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Protein Name | Histidine triad nucleotide-binding protein 1 |
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Organism | Bos taurus |
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Uniprot ID | P62958 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_787006.1 |
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Aminoacid Length | 126 |
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Molecular Weight | 13779 |
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FASTA Sequence |
Download |
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Gene Name | HINT1 |
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Gene ID | 327693 |
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Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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Protein Function | The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate. |
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Biochemical Properties | Histidine-triad nucleotide-binding protein 1 (HINT1) belongs to a histidine-triad (HIT) protein superfamily that has a characteristic C-terminal active-site motif HXHXHXX, where X is a hydrophobic residue.HINT homologues are present in a wide variety of organismsincluding the metazoan, plant, fungal and bacterial kingdoms. |
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PTMs | Phosphorylation at Serine,N6-Acetylation at Lys and N-acetylation at Ala |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | 1.Dolot R, Ozga M, Krakowiak A, Nawrot B. High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution. Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):601-7. doi: 10.1107/S0907444911015605. Epub 2011 Jun 14. PMID: 21697598. 2.Chen Q, Wang X, O'Neill FA, Walsh D, Kendler KS, Chen X. Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia? Schizophr Res. 2008 Dec;106(2-3):200-7. doi: 10.1016/j.schres.2008.08.006. Epub 2008 Sep 16. PMID: 18799291; PMCID: PMC2729541. 3.Brenner, C. (2002) .Biochemistry, 41 ,9003-9014 |