Search by BoMiProt ID - Bomi2315


Primary Information

BoMiProt ID Bomi2315
Protein Name Histidine triad nucleotide-binding protein 1
Organism Bos taurus
Uniprot IDP62958
Milk FractionExosome
Ref Sequence ID NP_787006.1
Aminoacid Length 126
Molecular Weight 13779
FASTA Sequence Download
Gene Name HINT1
Gene ID 327693
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate. 
Biochemical Properties Histidine-triad nucleotide-binding protein 1 (HINT1) belongs to a histidine-triad (HIT) protein superfamily that has a characteristic C-terminal active-site motif HXHXHXX, where X is a hydrophobic residue.HINT homologues are present in a wide variety of organismsincluding the metazoan, plant, fungal and bacterial kingdoms.
PTMs Phosphorylation at Serine,N6-Acetylation at Lys and N-acetylation at Ala
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Dolot R, Ozga M, Krakowiak A, Nawrot B. High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution. Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):601-7. doi: 10.1107/S0907444911015605. Epub 2011 Jun 14. PMID: 21697598. 2.Chen Q, Wang X, O'Neill FA, Walsh D, Kendler KS, Chen X. Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia? Schizophr Res. 2008 Dec;106(2-3):200-7. doi: 10.1016/j.schres.2008.08.006. Epub 2008 Sep 16. PMID: 18799291; PMCID: PMC2729541. 3.Brenner, C. (2002) .Biochemistry, 41 ,9003-9014