Primary Information
BoMiProt ID	Bomi231
Protein Name	Ataxin-10
Organism	Bos taurus
Uniprot ID	Q2TBW0
Milk Fraction	MFGM
Ref Sequence ID	NP_001070519.1
Aminoacid Length	475
Molecular Weight	53102
FASTA Sequence	Download
Gene Name	ATXN10
Gene ID	767990
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	exclusively found in the cytosolic fraction of cell lysates
Protein Function	essential for the survival of this subpopulation of neurons. Ataxin-10 inhibits endothelial cell activation and may serve as a promising therapeutic target for some vascular inflammatory-related diseases such as atherosclerosis.
Biochemical Properties	member of the armadillo repeat protein family with an all- -helical fold; tendency for homo-oligomerization
PTMs	Omega-N-methylation at Arginine,Phosphorylation at Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. März, P. et al. (2004) ‘Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.’, The Journal of biological chemistry, 279(34), pp. 35542–50. doi: 10.1074/jbc.M405865200. 2.Li Y, Zhang Q, Li N, Ding L, Yi J, Xiao Y, Chen S, Huang X. Ataxin-10 Inhibits TNF-α-Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1. Mediators Inflamm. 2021 Nov 23;2021:7042148. doi: 10.1155/2021/7042148. PMID: 34858081; PMCID: PMC8632433.