Primary Information |
---|
BoMiProt ID | Bomi2305 |
---|
Protein Name | General transcription factor II-I |
---|
Organism | Bos taurus |
---|
Uniprot ID | A7MB80 |
---|
Milk Fraction | Exosome |
---|
Ref Sequence ID | NP_001095647.1 |
---|
Aminoacid Length | 978 |
---|
Molecular Weight | 110125 |
---|
FASTA Sequence |
Download |
---|
Gene Name | GTF2I |
---|
Gene ID | 534669 |
---|
Protein Existence Status | Reviewed: Experimental evidence at transcript level |
---|
Secondary Information |
---|
Protein Function | TFII-I is a signal-induced multifunctional transcription factor and it is extremely important for human health and disease. |
---|
Biochemical Properties | An unusual structural characteristic of TFII-I family members is the presence of a repeated amino acid domain each containing a putative helix-loop-helix HLH-motif characterizing a protein–protein interaction module. TFII-I has six such repeated domains. |
---|
PTMs | Phosphorylation at Ser/Thr,N6-acetylation at Lysine,Isopeptide bond,Ubl conjugation |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
---|
Predicted Disorder Regions | 208-323, 641-660, 666-693, 795-816, 939-978 |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Significance of PTMs | Tyrosine phosphorylation by Src-family kinase of TFII-I facilitates its nuclear translocation also converts a portion of TFII-I into a transcriptional repressor.Phosphorylation on Tyr-248,377 and 482 contributes to BTK-mediated transcriptional activation. |
---|
Additional Comments | Gain-of function mutations in the coding regions are found in indolent thymic epithelial tumors (TETs) and Angioimmunoblastic T-cell lymphoma (AITL), suggesting an oncogenic function of TFII-I. |
---|
Bibliography | 1.Bu Y, Gao L, Gelman IH. Role for transcription factor TFII-I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src. Int J Cancer. 2011 Apr 15;128(8):1836-42. doi: 10.1002/ijc.25524. PMID: 20568114; PMCID: PMC2997892. 2.Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG EMBO J. 1997 Dec 1; 16(23):7091-104. 3. Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later.Roy AL Gene. 2012 Jan 15; 492(1):32-41. |