Primary Information |
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| BoMiProt ID | Bomi2300 |
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| Protein Name | Glutathione peroxidase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P00435 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_776501.1 |
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| Aminoacid Length | 205 |
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| Molecular Weight | 22659 |
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| FASTA Sequence |
Download |
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| Gene Name | GPX1 |
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| Gene ID | 281209 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. |
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| Biochemical Properties | The selenoenzyme glutathione peroxidase(GSH-Px) is a tetramer of identical subunits each exhibiting a molecular weight of 21kDa. |
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| PTMs | Glycation at Lys-110,Phosphorylation at Serine,N6-acetylation at Lys |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | The effects of glycation decides the hydrogen bond distances between carbonyl oxygen and nitrogen atoms of hydrogen bonded pairs in the active site helix of glutathione peroxidase.In the presence of water, there are significant increases in the hydrogen bond distances of Thi-48, Val-49, Tyr-52 and Thr-53, as a result of glycation of glutathione peroxidase by molecular modelling. |
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| PDB ID | 1GP1, |
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| Bibliography | 1.Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. PMID: 21087145; PMCID: PMC3159114. 2.Baldwin JS, Lee L, Leung TK, Muruganandam A, Mutus B. Identification of the site of non-enzymatic glycation of glutathione peroxidase: rationalization of the glycation-related catalytic alterations on the basis of three-dimensional protein structure. Biochim Biophys Acta. 1995 Feb 22;1247(1):60-4. doi: 10.1016/0167-4838(94)00202-r. PMID: 7873592. |
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