Protein Function | ApoA-IV is primarily
synthesized by the small intestine, attached to chylomicrons
by enterocytes, and secreted into intestinal lymph during fat
absorption; anti-oxidative and anti-infl ammatory
properties, and because it can mediate reverse-cholesterol
transport; The presence of apoA-IV in the
blood is uniquely linked to the absorption and secretion
of dietary lipid; very important
in the integrated control of food intake, metabolism,
and glucose homeostasis |
---|
Bibliography | 1. Utermann, G., & Beisiegel, U. (1979). Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification. European Journal of Biochemistry, 99(2), 333–343. https://doi.org/10.1111/j.1432-1033.1979.tb13261.x. 2. Green, P. H., Glickman, R. M., Riley, J. W., & Quinet, E. (1980). Human apolipoprotein A-IV. Intestinal origin and distribution in plasma. The Journal of Clinical Investigation, 65(4), 911–919. https://doi.org/10.1172/JCI109745. 3. Borghini, I., Barja, F., Pometta, D., & James, R. W. (1995). Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1255(2), 192–200. https://doi.org/10.1016/0005-2760(94)00232-N. 4. Karathanasis, S. K. (1985). Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proceedings of the National Academy of Sciences of the United States of America, 82(19), 6374–6378. https://doi.org/10.1073/pnas.82.19.6374. 5. Kalogeris, T. J., Fukagawa, K., & Tso, P. (1994). Synthesis and lymphatic transport of intestinal apolipoprotein A-IV in response to graded doses of triglyceride. Journal of Lipid Research, 35(7), 1141–1151. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7964177. |