Search by BoMiProt ID - Bomi220


Primary Information

BoMiProt ID Bomi220
Protein Name Apolipoprotein A-IV
Organism Bos taurus
Uniprot IDQ32PJ2
Milk FractionWhey, MFGM
Ref Sequence ID NP_001032557.1
Aminoacid Length 380
Molecular Weight 43018
FASTA Sequence Download
Gene Name APOA4
Gene ID 537301
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells major protein component of chylomicrons in postprandial lymph and plasma of both humans and rats; apoA-IV is also found in bile and cerebrospinal fl uid
Protein Function ApoA-IV is primarily synthesized by the small intestine, attached to chylomicrons by enterocytes, and secreted into intestinal lymph during fat absorption; anti-oxidative and anti-infl ammatory properties, and because it can mediate reverse-cholesterol transport; The presence of apoA-IV in the blood is uniquely linked to the absorption and secretion of dietary lipid; very important in the integrated control of food intake, metabolism, and glucose homeostasis
Biochemical Properties lipid-free apoA-IV exists primarily as a homodimer; lipid binds to this structure initially in a central hydrophobic pocket, and as more lipid is incorporated, the hydrophobic regions of the end and central bundles relax away from each other to accommodate, eventually forming a disc-like and ultimately spherical particle; stimulated by lipid absorption
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions (361-380)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Utermann, G., & Beisiegel, U. (1979). Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification. European Journal of Biochemistry, 99(2), 333–343. https://doi.org/10.1111/j.1432-1033.1979.tb13261.x.
2. Green, P. H., Glickman, R. M., Riley, J. W., & Quinet, E. (1980). Human apolipoprotein A-IV. Intestinal origin and distribution in plasma. The Journal of Clinical Investigation, 65(4), 911–919. https://doi.org/10.1172/JCI109745.
3. Borghini, I., Barja, F., Pometta, D., & James, R. W. (1995). Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1255(2), 192–200. https://doi.org/10.1016/0005-2760(94)00232-N.
4. Karathanasis, S. K. (1985). Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proceedings of the National Academy of Sciences of the United States of America, 82(19), 6374–6378. https://doi.org/10.1073/pnas.82.19.6374.
5. Kalogeris, T. J., Fukagawa, K., & Tso, P. (1994). Synthesis and lymphatic transport of intestinal apolipoprotein A-IV in response to graded doses of triglyceride. Journal of Lipid Research, 35(7), 1141–1151. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7964177.