Search by BoMiProt ID - Bomi216


Primary Information

BoMiProt ID Bomi216
Protein Name Annexin A4
Organism Bos taurus
Uniprot IdP13214
Milk FractionMFGM, Exosome
Ref Sequence Id NP_001001440.2
Amino Acid Lenth 319
Molecular Weight 35889
Fasta Sequence https://www.uniprot.org/uniprot/P13214.fasta
Gene Name ANXA4
Gene Id 281625
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Protein Function inhibit the Cl channel through a direct protein-protein interaction; part of a complex signaling pathway involving both protein kinases and intracellular Ca2 +; involved in a direct molecular interplay with the Ca2 -dependent Cl channel
Biochemical Properties Annexins IV were found in the nuclear fraction; Annexin IV from cytosolic and nuclear fractions had similar molecular masses and isoelectric points with mean pI of 7.0 and 7.3 respectively
PTMs phosphorylated by protein kinase C
PDB ID 1ANN, 1AOW, 1I4A,
Bibliography 1. Nilius, B., Gerke, V., Prenen, J., Szücs, G., Heinke, S., Weber, K., & Droogmans, G. (1996). Annexin II modulates volume-activated chloride currents in vascular endothelial cells. The Journal of Biological Chemistry, 271(48), 30631–30636. https://doi.org/10.1074/jbc.271.48.30631.
2. Katoh, N., Suzuki, T., Yuasa, A., & Miyamoto, T. (1995). Distribution of annexins I, II, and IV in bovine mammary gland. Journal of Dairy Science, 78(11), 2382–2387. https://doi.org/10.3168/jds.S0022-0302(95)76866-7.