Search by BoMiProt ID - Bomi212


Primary Information

BoMiProt ID Bomi212
Protein Name 4-trimethylaminobutyraldehyde dehydrogenase
Organism Bos taurus
Uniprot IdQ2KJH9
Milk FractionExosome
Ref Sequence Id NP_001039888.1
Amino Acid Lenth 494
Molecular Weight 53977
Fasta Sequence https://www.uniprot.org/uniprot/Q2KJH9.fasta
Gene Name ALDH9A1
Gene Id 537539
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function cytosolic NAD1-dependent aldehyde dehydrogenase; converts γ-trimethylaminobutyraldehyde into g-butyrobetaine; trimethyllysine released upon protein degradation is oxidized to γ-butyrobetaine (BB) by the action of trimethyllysine dioxygenase (TMLHE), 3-hydroxy-N-TML aldolase and 4-N-trimethylaminobutyraldehyde dehydrogenase
Significance in milk mRNA abundances of 4-N-trimethylaminobutyraldehyde dehydrogenase is increased in liver biopsy samples of cows in late pregnancy and early lactation
Bibliography 1. Schlegel, G., Keller, J., Hirche, F., Geissler, S., Schwarz, F. J., Ringseis, R., … Eder, K. (2012). Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation. BMC Veterinary Research, 8, 28. https://doi.org/10.1186/1746-6148-8-28.
2. Vaz, F. M., Fouchier, S. W., Ofman, R., Sommer, M., & Wanders, R. J. (2000). Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. The Journal of Biological Chemistry, 275(10), 7390–7394. https://doi.org/10.1074/jbc.275.10.7390.