Primary Information |
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| BoMiProt ID | Bomi2106 |
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| Protein Name | Ferritin heavy chain |
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| Organism | Bos taurus |
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| Uniprot ID | O46414 |
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| Milk Fraction | MFGM |
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| Ref Sequence ID | NP_776487.1 |
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| Aminoacid Length | 181 |
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| Molecular Weight | 21052 |
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| FASTA Sequence |
Download |
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| Gene Name | FTH1 |
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| Gene ID | 281173 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | The heavy chain subunit of ferritin (FHC), a ubiquitous protein best known for its iron-sequestering activity as part of the ferritin complex, has recently been described as a novel inhibitor of signaling through the chemokine receptor CXCR4. |
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| PTMs | N-acetylation at Meth/Thr,Phopshorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 1-15,65-69,173-181 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | FHC up-regulation may contribute to the neuronal dysfunction often associated with opiate drug abuse. |
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| Bibliography | Abt AC, Meucci O. Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction. J Neuroimmune Pharmacol. 2011 Dec;6(4):466-76. doi: 10.1007/s11481-011-9278-3. Epub 2011 Apr 5. PMID: 21465240; PMCID: PMC3763833. |
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