Primary Information |
|---|
| BoMiProt ID | Bomi2105 |
|---|
| Protein Name | Folate receptor alpha |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | P02702 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001193456.1 |
|---|
| Aminoacid Length | 241 |
|---|
| Molecular Weight | 27922 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | FOLR1 |
|---|
| Gene ID | 516067 |
|---|
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
|---|
Secondary Information |
|---|
| Protein Function | Folate receptor alpha (FR α) is a membrane-bound transport protein with several features which make it an attractive target for cancer immunotherapy. |
|---|
| PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn, GPI-anchor formation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
|---|
| Predicted Disorder Regions | 43-53,225-241 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor or by proteolysis catalyzed by a metalloprotease. |
|---|
| Bibliography | Clifton GT, Sears AK, Clive KS, Holmes JP, Mittendorf EA, Ioannides CG, Ponniah S, Peoples GE. Folate receptor α: a storied past and promising future in immunotherapy. Hum Vaccin. 2011 Feb;7(2):183-90. doi: 10.4161/hv.7.2.13784. Epub 2011 Feb 1. PMID: 21321484. |
|---|
