Search by BoMiProt ID - Bomi2103


Primary Information

BoMiProt ID Bomi2103
Protein Name Flotillin-1
Organism Bos taurus
Uniprot IDQ08DN8
Milk FractionMFGM, Exosome
Ref Sequence ID NP_001070355.1
Aminoacid Length 427
Molecular Weight 47353
FASTA Sequence Download
Gene Name FLOT1
Gene ID 532573
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways
Biochemical Properties The flotillin protein family consists of flotillin-1 and 2 (also called reggies) which homo- and hetero-oligomerize.
PTMs Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Down-regulation of flotillin-1 led to a reduction of the structural caveolae proteins caveolin-1, cavin-1 and -2, suggesting a role of flotillin-1 in caveolae formation. 
Bibliography 1.Wei J, Wang R, Lu Y, He S, Ding Y. Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways. Eur J Pharmacol. 2022 Feb 5;916:174631. doi: 10.1016/j.ejphar.2021.174631. Epub 2021 Nov 12. PMID: 34774850. 2.Fork C, Hitzel J, Nichols BJ, Tikkanen R, Brandes RP. Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol. 2014;109(6):439. doi: 10.1007/s00395-014-0439-4. Epub 2014 Sep 10. PMID: 25204797; PMCID: PMC4330457.