Primary Information |
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BoMiProt ID | Bomi2103 |
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Protein Name | Flotillin-1 |
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Organism | Bos taurus |
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Uniprot ID | Q08DN8 |
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Milk Fraction | MFGM, Exosome |
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Ref Sequence ID | NP_001070355.1 |
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Aminoacid Length | 427 |
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Molecular Weight | 47353 |
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FASTA Sequence |
Download |
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Gene Name | FLOT1 |
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Gene ID | 532573 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways |
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Biochemical Properties | The flotillin protein family consists of flotillin-1 and 2 (also called reggies) which homo- and hetero-oligomerize. |
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PTMs | Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Down-regulation of flotillin-1 led to a reduction of the structural caveolae proteins caveolin-1, cavin-1 and -2, suggesting a role of flotillin-1 in caveolae formation. |
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Bibliography | 1.Wei J, Wang R, Lu Y, He S, Ding Y. Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways. Eur J Pharmacol. 2022 Feb 5;916:174631. doi: 10.1016/j.ejphar.2021.174631. Epub 2021 Nov 12. PMID: 34774850. 2.Fork C, Hitzel J, Nichols BJ, Tikkanen R, Brandes RP. Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol. 2014;109(6):439. doi: 10.1007/s00395-014-0439-4. Epub 2014 Sep 10. PMID: 25204797; PMCID: PMC4330457. |