Primary Information |
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BoMiProt ID | Bomi2093 |
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Protein Name | Fatty acid synthase |
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Organism | Bos taurus |
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Uniprot ID | Q71SP7 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001012687.1 |
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Aminoacid Length | 2513 |
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Molecular Weight | 274554 |
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FASTA Sequence |
Download |
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Gene Name | FASN |
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Gene ID | 281152 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | Fatty acid synthase (FASN) functions as a central regulator of lipid metabolism and plays a critical role in the growth and survival of tumors with lipogenic phenotypes. |
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PTMs | N6-acetyllysine, Isopeptide bond formation, Phosphorylation at Ser/Thr,S-nitrosylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1977-1992,2114-2513 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | S-nitrosylation of Fatty acid synthase at Cys-1473 and 2093 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis. |
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Bibliography | Fhu CW, Ali A. Fatty Acid Synthase: An Emerging Target in Cancer. Molecules. 2020 Aug 28;25(17):3935. doi: 10.3390/molecules25173935. PMID: 32872164; PMCID: PMC7504791. |