Search by BoMiProt ID - Bomi2093


Primary Information

BoMiProt ID Bomi2093
Protein Name Fatty acid synthase
Organism Bos taurus
Uniprot IDQ71SP7
Milk FractionExosome
Ref Sequence ID NP_001012687.1
Aminoacid Length 2513
Molecular Weight 274554
FASTA Sequence Download
Gene Name FASN
Gene ID 281152
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Fatty acid synthase (FASN) functions as a central regulator of lipid metabolism and plays a critical role in the growth and survival of tumors with lipogenic phenotypes. 
PTMs N6-acetyllysine, Isopeptide bond formation, Phosphorylation at Ser/Thr,S-nitrosylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1977-1992,2114-2513
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs S-nitrosylation of Fatty acid synthase at Cys-1473 and 2093 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.
Bibliography Fhu CW, Ali A. Fatty Acid Synthase: An Emerging Target in Cancer. Molecules. 2020 Aug 28;25(17):3935. doi: 10.3390/molecules25173935. PMID: 32872164; PMCID: PMC7504791.