Primary Information
BoMiProt ID	Bomi2089
Protein Name	Fumarylacetoacetase
Organism	Bos taurus
Uniprot ID	A5PKH3
Milk Fraction	Exosome
Ref Sequence ID	NP_001092382.1
Aminoacid Length	419
Molecular Weight	46156
FASTA Sequence	Download
Gene Name	FAH
Gene ID	508724
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the tyrosine (Tyr) degradation pathway that is crucial for animals.FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle.
Biochemical Properties	Prokaryotic and eukaryotic fumarylacetoacetate hydrolase (FAH) superfamily members, sharing conserved regions that form the so-called FAH-domain, catalyze a remarkable variety of reactions.
PTMs	N-acetylation at Serine,Phosphorylation at Serine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Weiss AKH, Loeffler JR, Liedl KR, Gstach H, Jansen-Dürr P. The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria. Biochem Soc Trans. 2018 Apr 17;46(2):295-309. doi: 10.1042/BST20170518. Epub 2018 Feb 27. PMID: 29487229. 2.Weiss AKH, Wurzer R, Klapec P, Eder MP, Loeffler JR, von Grafenstein S, Monteleone S, Liedl KR, Jansen-Dürr P, Gstach H. Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1). Molecules. 2021 Aug 18;26(16):5009. doi: 10.3390/molecules26165009. PMID: 34443596; PMCID: PMC8398924.