Primary Information
BoMiProt ID	Bomi205
Protein Name	Abhydrolase domain-containing protein 4
Organism	Bos taurus
Uniprot ID	Q5EA59
Milk Fraction	MFGM, Exosome
Ref Sequence ID	NP_001029540.1
Aminoacid Length	342
Molecular Weight	38797
FASTA Sequence	Download
Gene Name	ABHD4
Gene ID	509896
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	ubiquitously expressed in multiple tissues, with highest expression in brain, small intestine, kidney and testis
Protein Function	An enzymatic regulator of endocannabinoid signaling and suppressor of tumor growth; play a role in tumor suppression through limiting cell proliferation and cell cycling; a lyso-N-acyl phosphatidylethanolamine lipase capable of hydrolyzing both N-acyl phosphatidylethanolamine (NAPE) and lysoNAPE to generate glycerophosphoarachidonyl ethanolamine; shows no enzymatic activity towards other lysophospholipid substrates; play an important role in cancer metastasis through a mechanism that does not involve its role in anandamide synthesis;
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Simon, G. M., & Cravatt, B. F. (2006). Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. The Journal of Biological Chemistry, 281(36), 26465–26472. https://doi.org/10.1074/jbc.M604660200. 2. Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., … Attardi, L. D. (2011). Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell, 145(4), 571–583. https://doi.org/10.1016/j.cell.2011.03.035. 3. Edgar, A. J., & Polak, J. M. (2002). Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Biochemical and Biophysical Research Communications, 292(3), 617–625. https://doi.org/10.1006/bbrc.2002.6692.