Search by BoMiProt ID - Bomi204


Primary Information

BoMiProt ID Bomi204
Protein Name ATP-binding cassette sub-family G member 2
Organism Bos taurus
Uniprot IdQ4GZT4
Milk FractionMFGM, Exosome
Ref Sequence Id XP_005207851.1
Amino Acid Lenth 655
Molecular Weight 72725
Fasta Sequence https://www.uniprot.org/uniprot/Q4GZT4.fasta
Gene Name ABCG2
Gene Id 536203
Protein Existence Status Reviewed: Protein inferred from homology

Secondry Information

Protein Function role in multidrug resistance (MDR) that efflux pumps as P-glycoprotein
Biochemical Properties half-transporter”, hypothetically comprising a transmembrane domain (TMD) with 6 α-helices that spawns the membrane bilayer and a nucleotide-binding domain (NBD) where ATP binds and hydrolyzes; includes a second canonical ABC signature (positions 352–356, LSGGE) also coupled with ATP binding and/or hydrolysis but not related with substrate specificity;
Significance in milk expressed in the bovine mammary gland at the onset of lactation; responsible for the major quantitave trait loci affecting milk yield and composition
PTMs intermolecular disulfide bond at position 603
Significance of PTMs ABCG2 homodimerization was due to the formation of an intermolecular disulfide bond at position 603
Bibliography 1. Ferreira, R. J., Bonito, C. A., Cordeiro, M. N. D. S., Ferreira, M. J. U., & Dos Santos, D. J. V. A. (2017). Structure-function relationships in ABCG2: Insights from molecular dynamics simulations and molecular docking studies. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-15452-z.
2. Cohen-Zinder, M., Seroussi, E., Larkin, D. M., Loor, J. J., Everts-van der Wind, A., Lee, J.-H., … Ron, M. (2005). Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Research, 15(7), 936–944. https://doi.org/10.1101/gr.3806705.