Primary Information |
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| BoMiProt ID | Bomi182 |
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| Protein Name | UNC45A protein |
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| Organism | Bos taurus |
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| Uniprot ID | A5PKJ5 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001092542.1 |
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| Aminoacid Length | 929 |
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| Molecular Weight | 101869 |
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| FASTA Sequence |
Download |
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| Gene Name | UNC45A |
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| Gene ID | 535692 |
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| Protein Existence Status | Unreviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | UNC45 isoform A is ubiquitous, whereas
isoform B is restricted to skeletal and cardiac muscle
expression |
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| Protein Function | Member
of the UCS family of myosin interacting
proteins; promotes myosin folding
and stress fibers assembly; UNC45A
contributes to tumorigenesis- expression in cancer cells is correlated with the stage
and the grade of the disease;UNC45A colocalizes
with non-muscle myosin II (NMII) in the
cleavage furrow during cytokinesis and to
centrosomes, to which it helps recruit checkpoint
kinase 1; UNC45A is a microtubule associated
protein that modulates the sensitivity of ovarian cancer cells to paclitaxel; UNC45A can regulate transcription of
the progesterone (PR), retinoic acid (RARα),
and peroxisome proliferator-activated receptors |
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| Biochemical Properties | UCS domain of UNC45B is
organized in helical armadillo repeats , which
cooperate with the N-terminal tetratricopeptide (TPR)
domain to recruit the heat shock protein 90 (Hsp90)
for myosin folding; Biochemically, both
isoforms interact with Hsp90 , but UNC45A
showed higher specificity toward Hsp90β; |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Bibliography | 1. Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., … Chadli, A. (2019). The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. The Journal of Biological Chemistry, 294(14), 5246–5260. https://doi.org/10.1074/jbc.RA118.006597 |
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