Search by BoMiProt ID - Bomi173


Primary Information

BoMiProt ID Bomi173
Protein Name STX6 protein
Organism Bos taurus
Uniprot IDA2VE18
Milk FractionExosome
Ref Sequence ID NP_001075900.1
Aminoacid Length 255
Molecular Weight 29073
FASTA Sequence Download
Gene Name STX6
Gene ID 510909
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells broadly expressed in tissues and cell lines
Protein Function Syntaxin 6 has several potential lysosomal sorting sequences; role in the targeting and fusion of TGN-derived vesicles with endosomes; implicated in trafficking to endosomes through its interaction with cellubrevin or VAMP-2; syntaxin 6 is a TGN receptor for incoming vesicles and that a low level of the protein resides on transport vesicles; plays a rate limiting role in cell migration and integrin trafficking
Biochemical Properties shows significant homology to syntaxin 3, Pep12, and SNAP-25;has a carboxyl-terminal membrane anchor directly preceded by a region predicted to form coiled-coils, and an amino-terminal region predicted to form coiled-coils; binds a-SNAP
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Bibliography 1. Bock, J. B., Lin, R. C., & Scheller, R. H. (1996). A new syntaxin family member implicated in targeting of intracellular transport vesicles. The Journal of Biological Chemistry, 271(30), 17961–17965. https://doi.org/10.1074/jbc.271.30.17961.
2. Bock, J. B., Klumperman, J., Davanger, S., & Scheller, R. H. (1997). Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Molecular Biology of the Cell, 8(7), 1261–1271. https://doi.org/10.1091/mbc.8.7.1261.
3. Riggs, K. A., Hasan, N., Humphrey, D., Raleigh, C., Nevitt, C., Corbin, D., & Hu, C. (2012). Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction. Journal of Cell Science, 125(Pt 16), 3827–3839. https://doi.org/10.1242/jcs.102566.