Search by BoMiProt ID - Bomi172


Primary Information

BoMiProt ID Bomi172
Protein Name Solute carrier organic anion transporter family, member 1A2
Organism Bos taurus
Uniprot IdA2VDW7
Milk FractionExosome
Ref Sequence Id XP_010803700.1
Amino Acid Lenth 666
Molecular Weight 73795
Fasta Sequence https://www.uniprot.org/uniprot/A2VDW7.fasta
Gene Name SLCO1A2
Gene Id 282472
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells brain, liver, and kidney; detected in the brain capillary endothelium in humans;
Protein Function drug uptake transporter; mediate the cellular uptake of a large number of structurally divergent compounds; play a critical role in the central nervous system penetration of many drugs and hormones across the blood-brain barrier
Biochemical Properties broad substrate specificity- Substrates of OATP1A2 include endogenous compounds such as bile acids, steroid hormones, and their conjugates, thyroid hormones, as well as drugs including fexofenadine, ouabain, peptides (e.g. deltorphin II, [D-penicillamine2,5]enkephalin, DPDPE), and the toxin, microcystin
Significance in milk play pivotal roles in the delivery of e.g. vitamins, fatty acids, sterols, porphyrins, thyroid hormones, carnitine, and amino acids to the breast-fed offspring; mediate active transport also of drugs and toxic chemicals into milk
PTMs when expressed in HeLa cells, five putative N-glycosylation sites were identified, including Asn residues at the amino acid positions of 62, 124, 412, and 483 as well as the 135 position
Bibliography 1. Yagdiran, Y., Oskarsson, A., Knight, C. H., & Tallkvist, J. (2016). ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz. PloS One, 11(3), e0151904. https://doi.org/10.1371/journal.pone.0151904.
2. Lee, W., Glaeser, H., Smith, L. H., Roberts, R. L., Moeckel, G. W., Gervasini, G., … Kim, R. B. (2005). Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2). Journal of Biological Chemistry, 280(10), 9610-9617 DO-10.1074/jbc.M411092200. https://doi.org/10.1074/jbc.M411092200.