Search by BoMiProt ID - Bomi172


Primary Information

BoMiProt ID Bomi172
Protein Name Solute carrier organic anion transporter family, member 1A2
Organism Bos taurus
Uniprot IdA2VDW7
Milk FractionExosome
Ref Sequence Id XP_010803700.1
Aminoacid Length 666
Molecular Weight 73795
Fasta Sequence https://www.uniprot.org/uniprot/A2VDW7.fasta
Gene Name SLCO1A2
Gene Id 282472
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells brain, liver, and kidney; detected in the brain capillary endothelium in humans;
Protein Function drug uptake transporter; mediate the cellular uptake of a large number of structurally divergent compounds; play a critical role in the central nervous system penetration of many drugs and hormones across the blood-brain barrier
Biochemical Properties broad substrate specificity- Substrates of OATP1A2 include endogenous compounds such as bile acids, steroid hormones, and their conjugates, thyroid hormones, as well as drugs including fexofenadine, ouabain, peptides (e.g. deltorphin II, [D-penicillamine2,5]enkephalin, DPDPE), and the toxin, microcystin
Significance in milk play pivotal roles in the delivery of e.g. vitamins, fatty acids, sterols, porphyrins, thyroid hormones, carnitine, and amino acids to the breast-fed offspring; mediate active transport also of drugs and toxic chemicals into milk
PTMs when expressed in HeLa cells, five putative N-glycosylation sites were identified, including Asn residues at the amino acid positions of 62, 124, 412, and 483 as well as the 135 position
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Bibliography 1. Yagdiran, Y., Oskarsson, A., Knight, C. H., & Tallkvist, J. (2016). ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz. PloS One, 11(3), e0151904. https://doi.org/10.1371/journal.pone.0151904.
2. Lee, W., Glaeser, H., Smith, L. H., Roberts, R. L., Moeckel, G. W., Gervasini, G., … Kim, R. B. (2005). Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2). Journal of Biological Chemistry, 280(10), 9610-9617 DO-10.1074/jbc.M411092200. https://doi.org/10.1074/jbc.M411092200.