Search by BoMiProt ID - Bomi170


Primary Information

BoMiProt ID Bomi170
Protein Name Coronin, actin binding protein, 1C
Organism Bos taurus
Uniprot IdA2VDN8
Milk FractionMFGM, Exosome
Ref Sequence Id NP_001075059.1
Amino Acid Lenth 474
Molecular Weight 53126
Fasta Sequence https://www.uniprot.org/uniprot/A2VDN8.fasta
Gene Name CORO1C
Gene Id 515798
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondry Information

Protein Function actin-binding protein that has been implicated in chemotaxis in Dictyostelium; participate in actin remodeling; serve as a bridge between the actin cytoskeleton and the plasma membrane due to its membrane association; required for phagocytosis; Coronin 1A localizes to the F-actin rich membrane protrusions of activated T-lymphocytes; Coronin 1A enhances (rather than inhibits) cofilin-mediated actin disassembly
Biochemical Properties undergoes reorganization during the polarization of the neutrophil, accumulating at the leading edge of the migrating cells
Significance in milk cell differentiation;cell growth/tissue development; defence/immunity; lipid droplet transport/secretion; MFG protein which was significantly increased in abundance after S. uberis infection
Bibliography 1. Thal, D., Xavier, C.-P., Rosentreter, A., Linder, S., Friedrichs, B., Waha, A., … Clemen, C. (2008). Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. The Journal of Pathology, 214(4), 415–424. https://doi.org/10.1002/path.2308.
2. Rosentreter, A., Hofmann, A., Xavier, C.-P., Stumpf, M., Noegel, A. A., & Clemen, C. S. (2007). Coronin 3 involvement in F-actin-dependent processes at the cell cortex. Experimental Cell Research, 313(5), 878–895. https://doi.org/10.1016/j.yexcr.2006.12.015.
3. Spoerl, Z., Stumpf, M., Noegel, A. A., & Hasse, A. (2002). Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. The Journal of Biological Chemistry, 277(50), 48858–48867. https://doi.org/10.1074/jbc.M205136200.