Search by BoMiProt ID - Bomi169


Primary Information

BoMiProt ID Bomi169
Protein Name Serpin A3-3
Organism Bos taurus
Uniprot IdQ3ZEJ6
Milk FractionWhey
Ref Sequence Id NP_001033293.1
Amino Acid Lenth 411
Molecular Weight 46326
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZEJ6.fasta
Gene Name SERPINA3-3
Gene Id 615103
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells hepatocytes, intestinal epithelial cells, neutrophils, lung epithelial cells, macrophages, human serum, saliva, tears, milk, semen, urine and bile
Protein Function antiprotease α1-antitrypsin; acute phase protein; major serine protease inhibitor of human serum; protectsthe fragile connective tissue of the lower respiratory tract from the uncontrolled proteolysis triggered by neutrophils during inflammation; has inhibitory properties with immunomodulatory and antiinflammatory activities against neutrophils, macrophages and other cell types; modulates neutrophil chemotaxis in response to soluble immune complexes by inhibiting ADAM-17 activity
Biochemical Properties strong affinity towards neutrophil elastase; irreversible inhibitor for kallikreins 7 and 14; inhibits intra-cellular and cell-surface proteases; inhibits the activity of caspase-3, an intra-cellular cysteine protease which plays an essential role in cell apoptosis;
Significance in milk inhibits thrombin activity
Bibliography 1. Chowanadisai, W., & Lönnerdal, B. (2002). Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability. The American Journal of Clinical Nutrition, 76(4), 828–833. https://doi.org/10.1093/ajcn/76.4.828.
2. Huang, C.-M. (2004). Comparative proteomic analysis of human whole saliva. Archives of Oral Biology, 49(12), 951–962. https://doi.org/10.1016/j.archoralbio.2004.06.003.
3. Luo, L.-Y., & Jiang, W. (2006). Inhibition profiles of human tissue kallikreins by serine protease inhibitors. Biological Chemistry, 387(6), 813–816. https://doi.org/10.1515/BC.2006.103.
4. Zhang, B., Lu, Y., Campbell-Thompson, M., Spencer, T., Wasserfall, C., Atkinson, M., & Song, S. (2007). Alpha1-antitrypsin protects beta-cells from apoptosis. Diabetes, 56(5), 1316–1323. https://doi.org/10.2337/db06-1273.
5. Petrache, I., Fijalkowska, I., Medler, T. R., Skirball, J., Cruz, P., Zhen, L., … Tuder, R. M. (2006). alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. The American Journal of Pathology, 169(4), 1155–1166. https://doi.org/10.2353/ajpath.2006.060058.
6. Bergin, D. A., Reeves, E. P., Meleady, P., Henry, M., McElvaney, O. J., Carroll, T. P., … McElvaney, N. G. (2010). α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. The Journal of Clinical Investigation, 120(12), 4236–4250. https://doi.org/10.1172/JCI41196.