Search by BoMiProt ID - Bomi168


Primary Information

BoMiProt ID Bomi168
Protein Name SPARC related modular calcium binding 1
Organism Bos taurus
Uniprot IDA0JNE0
Milk FractionExosome
Ref Sequence ID NP_001073239.1
Aminoacid Length 434
Molecular Weight 48103
FASTA Sequence Download
Gene Name SMOC1
Gene ID 508379
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells expressed by native murine endothelial cells; generally expressed in the basement membrane of different tissues; secreted from; In ovaries SMOC-1 is localized to the zona pellucida vascular endothelial cells
Protein Function Secreted modular calcium-binding protein 1 is a matricellular protein that potentially interferes with growth factor receptor signalling; highly expressed during development; can interact with laminins, CRP, fibulin-1, vitronectin, transglutaminase 2 and tenascin-C; can regulate endothelial cell function at least partly by binding to endoglin and acting as a negative feedback regulator of ALK5 signalling
Biochemical Properties member of the BM-40 family of proteins as defined by containing a pair of a follistatin-like (FS) domain and an extracellular calcium-binding (EC) domain
PTMs three predicted N-glycosylation sites- Asn-153, Asn-214, and Asn-374
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Bibliography 1. Awwad, K., Hu, J., Shi, L., Mangels, N., Abdel Malik, R., Zippel, N., … Fleming, I. (2015). Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. Cardiovascular Research, 106(2), 284–294. https://doi.org/10.1093/cvr/cvv098.
2. Vannahme, C., Smyth, N., Miosge, N., Gösling, S., Frie, C., Paulsson, M., … Hartmann, U. (2002). Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. The Journal of Biological Chemistry, 277(41), 37977–37986. https://doi.org/10.1074/jbc.M203830200.