Search by BoMiProt ID - Bomi155


Primary Information

BoMiProt ID Bomi155
Protein Name Zinc-alpha-2-glycoprotein
Organism Bos taurus
Uniprot IdQ3ZCH5
Milk FractionWhey
Ref Sequence Id NP_001029503.1
Amino Acid Lenth 299
Molecular Weight 33852
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZCH5.fasta
Gene Name AZGP1
Gene Id 508800
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells  serum, cerebrospinal fluid, urine, saliva,sweat, semen, amniotic fluid
Protein Function Stimulate lipolysis; potential biomarker for several carcinomas; has RNAse activity; regulation of melanin production; hinder tumor proliferation; transport of nephritic by-products; has important role in fertilization
Biochemical Properties serum ZAG has blocked NH2 terminus; seminal ZAG has free NH2 terminus; complexed with the prolactin-inducible protein found in human seminal fluid and has blocked NH2 terminus due to the presence of pyroglutamine; presence of high tryptophan and tyrosine residues; high extinction coefficient (E1%1cm) of 18.0; the amino acid sequence of ZAG contains four half-cystine residues; the position of cysteine and disulfide pairing reveals the bond formation in between residues 101 and 164 and second one between residues 203 and 258; the far-UV CD spectrum of the native ZAG measured at pH 7.4 and 25°C has an intense negative peak at 218 nm; shows a reversible thermal transition curve - CD signal changes at 218 nm, which disappeared gradually on heating the protein sample in the temperature range 25°C to 85°C; shows high stability in the absence of peptide and ß2M
Significance in milk Regulates lipid metabolism during lactation
PTMs Glycosylated; typical N-linked biantennary structure,substituted with N-acetylneuraminic acid in a 2,6 linkage and lacks fucose; 4 putative glycosylation sites; Asn 89, 92,106, 239; Asn 89,106, 239 carry glucosamines; Asn 239 is heavilly silalylated on mannose 2,6 arm;
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