Primary Information
BoMiProt ID	Bomi153
Protein Name	Serum amyloid P-component
Organism	Bos taurus
Uniprot ID	Q3T004
Milk Fraction	Whey
Ref Sequence ID	NP_001029638.1
Aminoacid Length	224
Molecular Weight	25183
FASTA Sequence	Download
Gene Name	APCS
Gene ID	514488
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	secreted from the liver and macrophages into the circulation
Protein Function	DNA and chromatin binding protein in plasma; soluble pattern recognition receptor of the innate immune system; function to aid in the removal of damaged tissue; regulate certain monocyte differentiation states; potentially powerful antifibrotic agent; plays role in coagulation and inflammation
Biochemical Properties	SAP binds, in a strictly calcium-dependent fashion to DNA and chromatin, glycosaminoglycans, and C4-binding protein at pH 5.5, the protein is a pentamer; at neutral pH in the presence of EDTA a stable decameric form exists; in the presence of calcium and absence of ligand, isolated SAP rapidly precipitates; presence of 2 calcium sites- bind to carbohydrate and synthetic ligand phophoethanolamine; resistant to proteolysis in the presence of calcium
PTMs	Glycosylated; a single N-linked biantennary oligosaccharide attached to Asn32
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Xi, D., Zhao, J., Guo, K., Hu, L., Chen, H., Fu, W., … Guo, Z. (2018). Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages. Theranostics, 8(12), 3214–3223. https://doi.org/10.7150/thno.22704. 2. Hohenester, E., Hutchinson, W. L., Pepys, M. B., & Wood, S. P. (1997). Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. Journal of Molecular Biology, 269(4), 570–578. https://doi.org/10.1006/jmbi.1997.1075.