Search by BoMiProt ID - Bomi149


Primary Information

BoMiProt ID Bomi149
Protein Name Gelsolin
Organism Bos taurus
Uniprot IdQ3SX14
Milk FractionWhey
Ref Sequence Id NP_001029799.1
Amino Acid Lenth 731
Molecular Weight 80731
Fasta Sequence https://www.uniprot.org/uniprot/Q3SX14.fasta
Gene Name GSN
Gene Id 535077
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function Gelsolin superfamily proteins have roles in a diversity of cellular processes; regulation of actin dynamics; antiapoptotic role; inhibit Aß-induced neurotoxicity; increased expression of gelsolin in oxidative stress helps cells to escape death
Biochemical Properties on calcium or pH signaling, gelsolin becomes activated and can sever actin filaments;
Significance in milk downregulated in clinical mastitis
Bibliography 1. Chauhan, V., Ji, L., & Chauhan, A. (2008). Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease. Biogerontology, 9(6), 381–389. https://doi.org/10.1007/s10522-008-9169-z.
2. Kiselar, J. G., Janmey, P. A., Almo, S. C., & Chance, M. R. (2003). Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3942–3947. https://doi.org/10.1073/pnas.0736004100.
3. Lueck, A., Yin, H. L., Kwiatkowski, D. J., & Allen, P. G. (2000). Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Biochemistry, 39(18), 5274–5279. https://doi.org/10.1021/bi992871v.