Search by BoMiProt ID - Bomi149

Primary Information

BoMiProt ID Bomi149
Protein Name Gelsolin
Organism Bos taurus
Uniprot IdQ3SX14
Milk FractionWhey
Ref Sequence Id NP_001029799.1
Amino Acid Lenth 731
Molecular Weight 80731
Fasta Sequence
Gene Name GSN
Gene Id 535077
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function Gelsolin superfamily proteins have roles in a diversity of cellular processes; regulation of actin dynamics; antiapoptotic role; inhibit Aß-induced neurotoxicity; increased expression of gelsolin in oxidative stress helps cells to escape death
Biochemical Properties on calcium or pH signaling, gelsolin becomes activated and can sever actin filaments;
Significance in milk downregulated in clinical mastitis
Bibliography 1. Chauhan, V., Ji, L., & Chauhan, A. (2008). Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease. Biogerontology, 9(6), 381–389.
2. Kiselar, J. G., Janmey, P. A., Almo, S. C., & Chance, M. R. (2003). Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3942–3947.
3. Lueck, A., Yin, H. L., Kwiatkowski, D. J., & Allen, P. G. (2000). Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Biochemistry, 39(18), 5274–5279.