Search by BoMiProt ID - Bomi149


Primary Information

BoMiProt ID Bomi149
Protein Name Gelsolin
Organism Bos taurus
Uniprot IdQ3SX14
Milk FractionWhey
Ref Sequence Id NP_001029799.1
Aminoacid Length 731
Molecular Weight 80731
Fasta Sequence https://www.uniprot.org/uniprot/Q3SX14.fasta
Gene Name GSN
Gene Id 535077
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Gelsolin superfamily proteins have roles in a diversity of cellular processes; regulation of actin dynamics; antiapoptotic role; inhibit Aß-induced neurotoxicity; increased expression of gelsolin in oxidative stress helps cells to escape death. Gelsolin is a calcium-regulated actin binding protein that severs and caps actin filaments. Gelsolin's severing activity is important for regulating actin filament assembly dynamics that are required for cell motility as well as survival.
Biochemical Properties on calcium or pH signaling, gelsolin becomes activated and can sever actin filaments;
Significance in milk downregulated in clinical mastitis
PTMs N6-acetylation at Lysine, Disulfide bond formation, Phosphorylation at Tyr/Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions (197-216)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Chauhan, V., Ji, L., & Chauhan, A. (2008). Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease. Biogerontology, 9(6), 381–389. https://doi.org/10.1007/s10522-008-9169-z.
2. Kiselar, J. G., Janmey, P. A., Almo, S. C., & Chance, M. R. (2003). Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3942–3947. https://doi.org/10.1073/pnas.0736004100.
3. Lueck, A., Yin, H. L., Kwiatkowski, D. J., & Allen, P. G. (2000). Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Biochemistry, 39(18), 5274–5279. https://doi.org/10.1021/bi992871v. 4.Heidings JB, Demosthene B, Merlino TR, Castaneda N, Kang EH. Gelsolin-mediated actin filament severing in crowded environments. Biochem Biophys Res Commun. 2020 Nov 19;532(4):548-554. doi: 10.1016/j.bbrc.2020.08.041. Epub 2020 Sep 6. PMID: 32900483.