Search by BoMiProt ID - Bomi147


Primary Information

BoMiProt ID Bomi147
Protein Name Complement C3
Organism Bos taurus
Uniprot IdQ2UVX4
Milk FractionWhey
Ref Sequence Id NP_001035559.2
Amino Acid Lenth 1661
Molecular Weight 187253
Fasta Sequence http://www.uniprot.org/uniprot/Q2UVX4.fasta
Gene Name C3
Gene Id 280677
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells serum,
Protein Function Component of innate immune system; host mechanism for detection and clearance of potential pathogens; stimulates mast cell degranulation, plays an important role in chemotaxis and serves as a precursor of the acylation stimulating protein through its interaction with carboxypeptidase B; special marker of chronic inflammation
Significance in milk Protection o mammary gland; increased resistance to breast-fed infants against infections; defeciency leads to an increased risk of mastitis;
PTMs Glycosylated; N-linked high-mannose carbohydrate moieties are attached at residues 917 of the α-chain and 63 of the ß-chain
PDB ID 2b39,
Bibliography 1. Hase, S., Kikuchi, N., Ikenaka, T., and Inoue, K. (1985) Structures of sugar chains of the third component of human complement. J. Biochem. 98, 863–874.
2. Prentice, A., Prentice, A. M., and Lamb, W. H. (1985) Mastitis in rural Gambian mothers and the protection of the breast by milk antimicrobial factors. Trans. R. Soc. Trop. Med. Hyg. 79, 90–95.
3. Buescher, E. S. (2001) Anti-inflammatory characteristics of human milk: how, where, why. Adv. Exp. Med. Biol. 501, 207–222.
4. Széplaki, G., Prohászka, Z., Duba, J., Rugonfalvi-Kiss, S., Karádi, I., Kókai, M., Kramer, J., Füst, G., Kleiber, M., Romics, L., and Varga, L. (2004) Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women. Atherosclerosis 177, 383–389.
5. Hirani, S., Lambris, J. D., and Müller-Eberhard, H. J. (1986) Structural analysis of the asparagine-linked oligosaccharides of human complement component C3. Biochem. J. 233, 613–616.
6. Hase, S., Kikuchi, N., Ikenaka, T., and Inoue, K. (1985) Structures of sugar chains of the third component of human complement. J. Biochem. 98, 863–874.