Search by BoMiProt ID - Bomi144


Primary Information

BoMiProt ID Bomi144
Protein Name Tetranectin
Organism Bos taurus
Uniprot IdQ2KIS7
Milk FractionWhey
Ref Sequence Id NP_001039677.1
Amino Acid Lenth 202
Molecular Weight 22144
Fasta Sequence https://www.uniprot.org/uniprot/Q2KIS7.fasta
Gene Name CLEC3B
Gene Id 515783
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells including monocytes, neutrophils, fibroblasts, osteoblasts, extracellular matrix of certain human carcinomas (breast, colonic, and ovarian tumors
Protein Function role in the invasive process, in mineralization during osteogenesis; target plasminogen to specific carbohydrate ligands on cell surfaces, in the extracellular matrix or to fibrin
Biochemical Properties homotrimeric protein; bind specifically to the kringle 4 domain of plasminogen; interacts in a calcium-dependent manner with sulfated polysaccharides, fibrin and apolipoprotein; contains a carbohydrate recognition domain
Significance in milk Expression increases during mammary involution process
PTMs contains a long-form carbohydrate recognition domain with three disulfide bridges
Bibliography 1. Boggs, I., Hine, B., Smolenski, G., Hettinga, K., Zhang, L., & Wheeler, T. T. (2015). Changes in the repertoire of bovine milk proteins during mammary involution. EuPA Open Proteomics, 9, 65–75. https://doi.org/10.1016/j.euprot.2015.09.001.
2. Nielsen, B. B., Kastrup, J. S., Rasmussen, H., Holtet, T. L., Graversen, J. H., Etzerodt, M., … Larsen, I. K. (1997). Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. FEBS Letters, 412(2), 388–396. https://doi.org/10.1016/s0014-5793(97)00664-9.