Primary Information
BoMiProt ID	Bomi135
Protein Name	Annexin A5
Organism	Bos taurus
Uniprot ID	P81287
Milk Fraction	Whey
Aminoacid Length	321
Molecular Weight	36089
FASTA Sequence	Download
Gene Name	ANXA5
Protein Existence Status	Reviewed: Experimental evidence at protein level
Secondary Information
Protein Function	regulating membrane-cytoskeleton dynamics; an association with the platelet membrane of cytosolic phospholipase A2, suggests an interaction between this phospholipase and annexin A5
Biochemical Properties	in the absence Ca2+ of Annexin A5 binds to and penetrates the bilayer of phosphatidylserine (PS) vesicles at pH 4; induce a leakage of PS vesicles at pH 5; neutral pH Ca2 binding to the protein appears to be a prerequisite for the lipid interaction; Ammexin A5 is a PKC inhibitor;
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Zhang, M., Chen, D., Zhen, Z., Ao, J., Yuan, X., & Gao, X. (2018). Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway. Journal of Cellular Physiology, 233(3), 2464–2475. https://doi.org/10.1002/jcp.26123. 2. Rosengarth, A., Gerke, V., & Luecke, H. (2001). X-ray structure of full-length annexin 1 and implications for membrane aggregation. Journal of Molecular Biology, 306(3), 489–498. https://doi.org/10.1006/jmbi.2000.4423. 3. Rescher, U., Zobiack, N., & Gerke, V. (2000). Intact Ca(2+)-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells. Journal of Cell Science, 113 ( Pt 22), 3931–3938. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11058080.