Search by BoMiProt ID - Bomi132


Primary Information

BoMiProt ID Bomi132
Protein Name Angiogenin2
Organism Bos taurus
Uniprot IDP80929
Milk FractionWhey
Aminoacid Length 123
Molecular Weight 14522
FASTA Sequence Download
Gene Name ANG2
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function cell adhesion , nuclear translocation , actin binding , inhibition of cell-free translation or hydrolysis of tRNA; highly active in inducing blood-vessel growth
Biochemical Properties basic angiogenic protein that binds tightly to placental ribonuclease inhibitor; the amino-terminal and carboxyl-terminal residues are pyroglutamic acid and proline; ribonucleolytic activity that is similar to, but somewhat lower than bovine angiogenin 1; angiogenically potent on chicken chorioallantoic membrane; bovine angiogenin-2 was 20 kDa, larger than that of bovine angiogenin-I (14kDa)
Significance in milk Milk contains considerably more bovine angiogenin than does serum; binds to PRI but had very little RNase activit
PTMs cross-linked by three disulfide bonds, is glycosylated at Asn33; contained 5 - 6 mannose, 2- 3 glucosamine, 1-2 galactosamine, up to one xylose and no sialic acid residues;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P80929|ANG2_BOVIN Angiogenin-2 OS=Bos taurus OX=9913 GN=ANG2 PE=1 SV=1
QNDAYRGFLRKHYDPSPTGHDDRYCNTMMERRN*33MTRPCKDTNTFIHGNSDDIRAVCDDRN GEPYRNGLRRSRSPFQVTTCRHRGGSPRPPCRYRAFRANRVIVIRCRDGFPIHLEENFIP PRP
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs modification of bovine angiogenin-2 is on Am33 and should physically cover a large surface area of bovine angiogenin-2, as on RNase B, some modulation of nuclear translocation may be possible, even though bovine angiogenin-2 is an active angiogenic molecule
Bibliography 1. Strydom, D. J., Bond, M. D., & Vallee, B. L. (1997). An angiogenic protein from bovine serum and milk--purification and primary structure of angiogenin-2. European Journal of Biochemistry, 247(2), 535–544. https://doi.org/10.1111/j.1432-1033.1997.00535.