Search by BoMiProt ID - Bomi1272


Primary Information

BoMiProt ID Bomi1272
Protein Name Elongation factor 1-alpha 1
Organism Bos taurus
Uniprot IDP68103
Milk FractionMFGM, Exosome
Ref Sequence ID NP_776960.1
Aminoacid Length 462
Molecular Weight 50141
FASTA Sequence Download
Gene Name EEF1A1
Gene ID 282220
Protein Existence Status Reiewed: Experimental evidence at protein level

Secondary Information

Biochemical Properties Elongation factor-1 alpha (EF-1 alpha), which is known as an actin-binding protein besides a cofactor of polypeptide elongation.
PTMs N6-acetylation at Lysine,Phosphorylation at Ser/Tyr,N6,N6,N6-trimethylation at Lysine,Ubl Conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation by PASK increases translation efficiency.Trimethylated at Lys-79 and 318 by EEF1AKMT1 and EEF1AKMT2 respectively . Methylated at Lys-165 by EEF1AKMT3, which is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4.
Bibliography 1.Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K. Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun. 2000 Nov 11;278(1):72-8. doi: 10.1006/bbrc.2000.3772. PMID: 11071857.