Primary Information |
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BoMiProt ID | Bomi1272 |
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Protein Name | Elongation factor 1-alpha 1 |
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Organism | Bos taurus |
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Uniprot ID | P68103 |
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Milk Fraction | MFGM, Exosome |
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Ref Sequence ID | NP_776960.1 |
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Aminoacid Length | 462 |
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Molecular Weight | 50141 |
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FASTA Sequence |
Download |
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Gene Name | EEF1A1 |
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Gene ID | 282220 |
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Protein Existence Status | Reiewed: Experimental evidence at protein level |
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Secondary Information |
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Biochemical Properties | Elongation factor-1 alpha (EF-1 alpha), which is known as an actin-binding protein besides a cofactor of polypeptide elongation. |
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PTMs | N6-acetylation at Lysine,Phosphorylation at Ser/Tyr,N6,N6,N6-trimethylation at Lysine,Ubl Conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Phosphorylation by PASK increases translation efficiency.Trimethylated at Lys-79 and 318 by EEF1AKMT1 and EEF1AKMT2 respectively . Methylated at Lys-165 by EEF1AKMT3, which is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4. |
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Bibliography | 1.Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K. Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun. 2000 Nov 11;278(1):72-8. doi: 10.1006/bbrc.2000.3772. PMID: 11071857. |