Primary Information |
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BoMiProt ID | Bomi1270 |
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Protein Name | Excitatory amino acid transporter 3 |
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Organism | Bos taurus |
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Uniprot ID | Q95135 |
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Milk Fraction | MFGM, Exosome |
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Ref Sequence ID | NP_777024.1 |
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Aminoacid Length | 524 |
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Molecular Weight | 57297 |
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FASTA Sequence |
Download |
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Gene Name | SLC1A1 |
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Gene ID | 282353 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | The neuronal excitatory amino acid transporter 3 (EAAT3) is important in maintaining low local concentrations of glutamate.It is also the main neuronal cysteine uptake system acting as the rate-limiting factor for the synthesis of glutathione, a potent antioxidant, in EAAT3 expressing neurons, while on GABAergic neurons, it is important in supplying glutamate as a precursor for GABA synthesis. |
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PTMs | Phosphorylation at Ser,N-Linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | 8TMHs; (19-38), (58-80), (92-114), (204-226), (250-272), (287-309), (357-379), (389-411) |
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Bibliography | 1.Bjørn-Yoshimoto WE, Underhill SM. The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochem Int. 2016 Sep;98:4-18. doi: 10.1016/j.neuint.2016.05.007. Epub 2016 May 24. PMID: 27233497; PMCID: PMC4969196. |