Search by BoMiProt ID - Bomi1270


Primary Information

BoMiProt ID Bomi1270
Protein Name Excitatory amino acid transporter 3
Organism Bos taurus
Uniprot IDQ95135
Milk FractionMFGM, Exosome
Ref Sequence ID NP_777024.1
Aminoacid Length 524
Molecular Weight 57297
FASTA Sequence Download
Gene Name SLC1A1
Gene ID 282353
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function The neuronal excitatory amino acid transporter 3 (EAAT3) is important in maintaining low local concentrations of glutamate.It is also the main neuronal cysteine uptake system acting as the rate-limiting factor for the synthesis of glutathione, a potent antioxidant, in EAAT3 expressing neurons, while on GABAergic neurons, it is important in supplying glutamate as a precursor for GABA synthesis.
PTMs Phosphorylation at Ser,N-Linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 8TMHs; (19-38), (58-80), (92-114), (204-226), (250-272), (287-309), (357-379), (389-411)
Bibliography 1.Bjørn-Yoshimoto WE, Underhill SM. The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochem Int. 2016 Sep;98:4-18. doi: 10.1016/j.neuint.2016.05.007. Epub 2016 May 24. PMID: 27233497; PMCID: PMC4969196.