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Primary Information | |
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| BoMiProt ID | Bomi127 |
| Protein Name | Cathelicidin-5 |
| Organism | Bos taurus |
| Uniprot ID | P54229 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776935.1 |
| Aminoacid Length | 159 |
| Molecular Weight | 17616 |
| FASTA Sequence | Download |
| Gene Name | CATHL5 |
| Gene ID | 282167 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Protein Function | the effect of BMAP-28 on S. aureus may be complex and include promoting bacterial pathogenesis; increased adherence of S. aureus to host fibronectin, collagen type I and collagen type IV; spirochetes are susceptible to BMAP-28; antiparasitic activity against two strains of L. major; caused greater inhibition of release of lipoteichoic acid (LTA)-induced TNF-α, IL-6 and nitric oxide from Gram-positive bacteria; can induce immunomodulatory effects on leukocytes depending on the pathogen and surrounding cytokine milieu |
| Biochemical Properties | α-helical bovine myeloid antimicrobial peptides; hydrophobic C-terminal |
| Significance in milk | initial response of the mammary epithelium to microbial infection |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 1-5,55-76,88-97 |
| DisProt Annotation | |
| TM Helix Prediction | 1TMH; (13-31) |
| Significance of PTMs | Antimicrobial peptides and upregulated in mastitis |
| PDB ID | 2NDC, 2NDE, |
| Bibliography | 1. Giacometti, A., Cirioni, O., Ghiselli, R., Bergnach, C., Orlando, F., D’Amato, G., Mocchegiani, F., Silvestri, C., Del Prete, M. S., Skerlavaj, B., Saba, V., Zanetti, M., and Scalise, G. (2004) The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis. Crit. Care Med. 32, 2485–2490. 2. 1. Lynn, M. A., Kindrachuk, J., Marr, A. K., Jenssen, H., Panté, N., Elliott, M. R., Napper, S., Hancock, R. E., and McMaster, W. R. (2011) Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival. PLoS Negl. Trop. Dis. 5, e1141. 3. 1. Takagi, S., Bai, L., Ozeki, T., Miyagi, H., Kuroda, K., Hayashi, S., Yoneyama, H., Ando, T., and Isogai, E. (2014) A bovine myeloid antimicrobial peptide (BMAP-28) kills methicillin-resistant Staphylococcus aureus but promotes adherence of the bacteria. Anim. Sci. J. 85, 342–346. |