Primary Information |
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| BoMiProt ID | Bomi1242 |
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| Protein Name | Unconventional myosin-VI |
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| Organism | Bos taurus |
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| Uniprot ID | E1BPK6 |
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| Milk Fraction | Exosome |
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| Aminoacid Length | 1295 |
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| Molecular Weight | 149616 |
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| FASTA Sequence |
Download |
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| Gene Name | MYO6 |
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| Gene ID | 535127 |
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| Protein Existence Status | reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Myo6 is one of the unconventional myosins in oligodendrocyte lineage cells, which could play a role in clathrin-related endocytosis. Myo6 expression is also detected in mature oligodendrocytes and oligodendrocyte progenitor cells in the cerebellum and corpus callosum. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation in the motor domain is induced by EGF, results in the translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. |
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| Bibliography | Yamazaki R, Ishibashi T, Baba H, Yamaguchi Y. Expression of Unconventional Myosin VI in Oligodendrocytes. Neurochem Res. 2017 Dec;42(12):3372-3381. doi: 10.1007/s11064-017-2377-7. Epub 2017 Aug 21. PMID: 28828543. |
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