Search by BoMiProt ID - Bomi120


Primary Information

BoMiProt ID Bomi120
Protein Name Cathelicidin-4
Organism Bos taurus
Uniprot IdP33046
Milk FractionWhey
Ref Sequence Id NP_777252.1
Amino Acid Lenth 144
Molecular Weight 16479
Fasta Sequence https://www.uniprot.org/uniprot/P33046.fasta
Gene Name CATHL4
Gene Id 282166
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Protein Function smallest natural bovine cathelicidin; intermediate antibacterial activity with minimum inhibitory concentrations; inhibitory activity against P. aeruginosa biofilm formation at 16 μg/mL; anti-endotoxin activities, including inhibition of LPS-induced cytokine synthesis in leukocytes; At high concentrations, indolicidin becomes membranolytic, translocating across mammalian membranes to interact with internal cellular targets; potent fungicidal activity, including against C. neoformans, C. albicans;
Biochemical Properties proline and tryptophan-rich; highest tryptophan concentration of bovine cathelicidins; indolicidin displaces stabilizing divalent cations from the surface of LPS, which disrupts the bacterial outer membrane
Significance in milk initial response of the mammary epithelium to microbial infection
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
PDB ID 1G89, 1G8C, 1HR1, 1QX9, 1QXQ,
Bibliography 1. Falla, T. J., Karunaratne, D. N., and Hancock, R. E. (1996) Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 271, 19298–19303.
2. Pompilio, A., Scocchi, M., Pomponio, S., Guida, F., Di Primio, A., Fiscarelli, E., Gennaro, R., and Di Bonaventura, G. (2011) Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients. Peptides 32, 1807–1814.
3. Sahoo, B. R. and Fujiwara, T. (2016) Membrane Mediated Antimicrobial and Antitumor Activity of Cathelicidin 6: Structural Insights from Molecular Dynamics Simulation on Multi-Microsecond Scale. PLoS One 11, e0158702.
4. Das, H., Sharma, B., and Kumar, A. (2006) Cloning and characterization of novel cathelicidin cDNA sequence of Bubalus bubalis homologous to Bos taurus cathelicidin-4. DNA Seq. 17, 407–414.
5. Falla, T. J., Karunaratne, D. N., and Hancock, R. E. (1996) Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 271, 19298–19303.
6. Bowdish, D. M. E., Davidson, D. J., Scott, M. G., and Hancock, R. E. W. (2005) Immunomodulatory Activities of Small Host Defense Peptides. Antimicrob. Agents Chemother. 49, 1727–1732.
7. Benincasa, M., Scocchi, M., Pacor, S., Tossi, A., Nobili, D., Basaglia, G., Busetti, M., and Gennaro, R. (2006) Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts. J. Antimicrob. Chemother. 58, 950–959