Search by BoMiProt ID - Bomi118


Primary Information

BoMiProt ID Bomi118
Protein Name Spermadhesin-1
Organism Bos taurus
Uniprot IdP29392
Milk FractionWhey
Ref Sequence Id NP_777041.1
Amino Acid Lenth 134
Molecular Weight 15036
Fasta Sequence https://www.uniprot.org/uniprot/P29392.fasta
Gene Name SPADH1
Gene Id 282373
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells male genital tract of pig, horse and bulls, seminal vescicles, peripherally associated to the sperm surface,
Protein Function multifunctional proteins; involved in different steps of fertilization; represent a novel class of lectins that may be involved in sequential steps of fertilization; stimulates progesterone secretion and growth through cell division and in bovine granulosa cells in vitro
Biochemical Properties belong to the superfamily of proteins with a CUB domain with a predicted all-p structure;
Significance in milk potential protein candidate biomarkers of bovine pregnancy;
PDB ID 1SFP,
Bibliography 1. Johnston, D., Malo Estepa, I., Ebhardt, H. A., Crowe, M. A., & Diskin, M. G. (2018). Differences in the bovine milk whey proteome between early pregnancy and the estrous cycle. Theriogenology, 114, 301–307. https://doi.org/10.1016/j.theriogenology.2018.04.008.
2. Einspanier, R., Krause, I., Calvete, J. J., Töfper-Petersen, E., Klostermeyer, H., & Karg, H. (1994). Bovine seminal plasma aSFP: localization of disulfide bridges and detection of three different isoelectric forms. FEBS Letters, 344(1), 61–64. https://doi.org/10.1016/0014-5793(94)00362-9.
3. Romero, A., Romão, M. J., Varela, P. F., Kölln, I., Dias, J. M., Carvalho, A. L., … Calvete, J. J. (1997). The crystal structures of two spermadhesins reveal the CUB domain fold. Nature Structural Biology, 4(10), 783–788. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9334740.