Search by BoMiProt ID - Bomi109


Primary Information

BoMiProt ID Bomi109
Protein Name Angiogenin1
Organism Bos taurus
Uniprot IdP10152
Milk FractionWhey
Amino Acid Lenth 148
Molecular Weight 16970
Fasta Sequence https://www.uniprot.org/uniprot/P10152.fasta
Gene Name ANG1
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells liver, placenta, epthelial cells, fibroblasts, blood cells, serum
Protein Function Active inductor of vessel growth; maintenance of homeostasis in living organisms; regulates immune system
Biochemical Properties Homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His‐14, Lys‐41 and His‐115, are conserved; contains the cell recognition tripeptide Arg‐Gly‐Asp.
Significance in milk Induced production of cytokines in leukocytes;
PDB ID 1AGI, 1GIO,
Bibliography 1. Maes, P., Damart, D., Rommens, C., Montreuil, J., Spik, G., & Tartar, A. (1988). The complete amino acid sequence of bovine milk angiogenin. FEBS Letters, 241(1–2), 41–45. https://doi.org/10.1016/0014-5793(88)81027-5.
2. Shcheglovitova, O. N., Maksyanina, E. V., Ionova, I. I., Rustam’yan, Y. L., & Komolova, G. S. (2003). Cow milk angiogenin induces cytokine production in human blood leukocytes. Bulletin of Experimental Biology and Medicine, 135(2), 158–160. https://doi.org/10.1023/A:1023871931764.