Search by BoMiProt ID - Bomi10800


Primary Information

BoMiProt ID Bomi10800
Protein Name Zinc transporter ZIP11/Solute carrier family 39 member 11 Zrt- and Irt-like protein 11/ZIP-11
Organism Bos taurus
Uniprot IdQ2YDD4
Milk FractionWhey,exosome
Ref Sequence Id NP_001069858.1
Aminoacid Length 341
Molecular Weight 35198
Fasta Sequence https://www.uniprot.org/uniprot/Q2YDD4.fasta
Gene Name SLC39A11
Gene Id 615681
Protein Existence Status reviewed

Secondary Information

Protein Function cellular zinc transporter.absorption and metabolism of dietary zinc.
Biochemical Properties ZIP11 has 6 transmembrane domains with the N terminus having an extracellular location . histidine-rich loop is usually found in Zip transporter proteins
Significance in milk Human milk contains less zinc than does bovine milk, with zinc concentrations of both decreasing throughout lactation.Lowering the pH further decreased zinc bioavailability from human milk, but not from cow's milk.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1 disordered segment; (150-186)
DisProt Annotation
TM Helix Prediction 5TMHs; (15-33),(46-64),(73-95),(193-215) and (274-296)
Additional Comments when dietary zinc intake is compromised, the colon may increase zinc transporter expression to improve the efficiency for absorption via increased expression of specific zinc transporters, including ZIP11 and also zinc transporter Slc39a4
Bibliography Martin AB, Aydemir TB, Guthrie GJ, Samuelson DA, Chang SM, Cousins RJ. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8. doi: 10.3945/jn.113.184457. Epub 2013 Oct 2. PMID: 24089422; PMCID: PMC3827636.