Search by BoMiProt ID - Bomi10799


Primary Information

BoMiProt ID Bomi10799
Protein Name Zinc transporter ZIP1
Organism Bos taurus
Uniprot IdQ3SYU3
Milk FractionWhey
Ref Sequence Id NP_001030458.1
Aminoacid Length 324
Molecular Weight 34205
Fasta Sequence https://www.uniprot.org/uniprot/Q3SYU3.fasta
Gene Name SLC39A1
Protein Existence Status reviewed

Secondary Information

Protein Function It is involved in Zinc uptake mechanism and it may function as a zinc uptake transporter in different cell types.
PTMs glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions (1-5), (137-169)
DisProt Annotation
TM Helix Prediction 6TMHs; (33-51), (71-89) ,(108-126) ,(238-260), (279-297) & (304-322)
Significance of PTMs In zinc-limited cells of yeast, ZRT1 is a stable, N-glycosylated plasma membrane protein.
Bibliography 1.Gitan RS, Luo H, Rodgers J, Broderius M, Eide D. Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J Biol Chem. 1998 Oct 30;273(44):28617-24. doi: 10.1074/jbc.273.44.28617. PMID: 9786854. 2.Wang, P., Zhang, J., He, S., Xiao, B., & Peng, X. (2020). SLC39A1 contribute to malignant progression and have clinical prognostic impact in gliomas. Cancer cell international, 20(1), 573. https://doi.org/10.1186/s12935-020-01675-0