Search by BoMiProt ID - Bomi10782


Primary Information

BoMiProt ID Bomi10782
Protein Name Zinc finger protein 750
Organism Bos taurus
Uniprot IdA2VDR9
Milk FractionWhey
Ref Sequence Id NP_001075002.1
Aminoacid Length 703
Molecular Weight 75167
Fasta Sequence https://www.uniprot.org/uniprot/A2VDR9.fasta
Gene Name ZNF750
Gene Id 535628
Protein Existence Status reviewed

Secondary Information

Protein Function A transcription factor regulated by p63,plays a critical role in epithelial tissues homoeostasis
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 86-101, 410-421, 456-462, 495-524, 549-649
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments upregulation of ZNF750 inhibited the expression of b-catenin and the downstream targets (cyclin D1, c-Myc, Bcl-2, MMP2 and MMP9), indicating it could block the activation of Wnt/b-catenin pathway.
Bibliography Butera A, Cassandri M, Rugolo F, Agostini M, Melino G. The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. Cell Death Discov. 2020 Nov 29;6(1):135. doi: 10.1038/s41420-020-00371-2. PMID: 33298895; PMCID: PMC7701147.