Search by BoMiProt ID - Bomi10781


Primary Information

BoMiProt ID Bomi10781
Protein Name Zinc finger protein 746
Organism Bos taurus
Uniprot IdQ3B7M4
Milk FractionWhey
Ref Sequence Id NP_001030418.1
Aminoacid Length 630
Molecular Weight 67972
Fasta Sequence https://www.uniprot.org/uniprot/Q3B7M4.fasta
Gene Name ZNF746
Gene Id 521998
Protein Existence Status reviewed

Secondary Information

Protein Function promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.
Biochemical Properties ZNF746 is normally degraded through UPS by parkin activation, as ZNF746 is a substrate of the ubiquitin E3 ligase parkin [
PTMs Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments ZNF746 was overexpressed in HCT116, SW620, and SW480 cells, which was supported by CRC tissue microarray and TCGA analysis. 
Bibliography Jung JH, Jung DB, Kim H, Lee H, Kang SE, Srivastava SK, Yun M, Kim SH. Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7. Oncogene. 2018 Jul;37(27):3715-3728. doi: 10.1038/s41388-018-0225-0. Epub 2018 Apr 9. PMID: 29628506.